|
KMID : 0369819950250010031
|
|
Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 1 p.31 ~ p.36
|
|
|
Enhancement of Dissolution Rate of Poorly Water-soluble Inbuprofen Using Solid Dispersions and Inclusion complex
|
|
|
|
|
Abstract
|
|
|
Solid dispersions and inclusion complex were prepared for the enhancement of solubility and dissolution rate of poorly water-soluble ibuprofen(IPF) as a model drug. Polyethylene glycol 4000(PEG4000)and polyvinylpyrrolidone(PVP)were used for the
preparation of solid dispersion. 2-Hydroxypropyl-β-cyclodextrin(2-HPβCD) was also used for the preparation of inclusion complex. The solubility of IPF increased as the concentration of PEG4000, PVP and 2-HPβCD increased. Solubilization
capacity
of
2-HPβCD was increased about 10times when compared to PEG 4000 PVP. The dissolution rate of drug from solid dispersions and inclusion complex in the simulated gastric fluid was enhanced when compared to pure IPF and commercial BR4(r) tablet as a
result
of improvement of solubility. In case of solid dispersions, dissolution rate of drug was proportional to polymer concentration in the formulation. The marked enhancement of dissolution rate of drug by inclusion complexation with 2-HPβCD was
noted.
However, dissolution rate of drug from solid dispersions and inclusion complex in the simulated intestinal fluid was not significant because IPF was readily soluble in that condition. Form these findings, water-soluble polymers and cyclodextrin
were
useful to improve solubility and dissolution rate of poorly water-soluble drugs. However, easiness and reliability of preparation method. Scale-up and cost of raw materials must be considered for the practical application of solid dispersion and
inclusion complex in pharmaceutical industry.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|